Patient-maintained propofol TCI sedation (PMPS) allows patients to titrate their own target-controlled infusion (TCI) delivery of propofol sedation using a handheld button. The aim of this RCT was to compare PMPS with anaesthetist-controlled propofol TCI sedation (ACPS) in patients undergoing elective primary lower-limb arthroplasty surgery under spinal anaesthesia.


David W. Hewson, Nottingham University Hospitals, Queen’s Medical Centre, Department of Anaesthesia and Critical Care Medicine
Frank Worcester, Nottingham Trent University, Medical Engineering Design Research Group
James Sprinks, Nottingham Trent University, Medical Engineering Design Research Group
Murray D. Smith, University of Lincoln, Community and Health Research Unit
Heather Buchanan, University of Nottingham, Division of Rehabilitation and Ageing
Philip Breedon, Nottingham Trent University, Medical Engineering Design Research Group
Jonathan G. Hardman, Nottingham University Hospitals, Queen’s Medical Centre, Department of Anaesthesia and Critical Care Medicine
Nigel M. Bedforth, Nottingham University Hospitals, Queen’s Medical Centre, Department of Anaesthesia and Critical Care Medicine